Chemical Development for a Surgical Fluid Disposal System

Client

Cannot disclose due to confidentiality agreement.

Challenge

Determine appropriate chemicals to include in a surgical fluids container to keep the blood from clotting, keep the foam levels down (to enable volume measurements) and to provide some measure of antibiotic activity (in case a spill would occur). The chemicals need to remain effective over a period of up to 48 hours. The term "remain effective" is to mean active at chemical levels near the initial levels.

Solution

Aspen conducted this work in three phases:

Extensive literature search and technological ideation sessions to determine credible paths

A screening was done to show general efficacy of the best bet chemical systems and to develop able methods of analysis for the ingredient chemical species.

A "proof of concept" was performed to evaluate the "top candidate" mix of chemicals as to their ability to reach an optimum concentration quickly, their stability, and their propensity to interact or to act with blood to form potentially hazardous gases.

We were able to settle on a stable chemical system and to show that it was suitably soluble, that the individual reagents were stable in the blend for at least 48 hours of use, and that no observable volatiles were formed that might lead to concern about product stability or safety. We also provided back up reagents in case an unforeseen dysfunction crops up in future biological trials.

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